The film revolves around Karthik (Ananth Nag), a happy-go-lucky youngster who is obsessed with astrology. One day, he and his friend (Kadhal Sugumar) come across a drug dealer which lands them in trouble. What was supposed to be a thriller then becomes a series of unengaging sequences, thanks to underdeveloped characters and low production values. The core plot surrounding astrology was left unexplored after a point. With an aimless screenplay, unnecessary songs, weak humour, ineffective twists and strictly okayish performances from the two lead characters, Thiruvalar Panchankam becomes a tedious affair.

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