Fired from her clinic job of researching erectile dysfunction, Jesse Jane and her newly unemployed co-worker Lilly Banks want to continue helping guys find pleasure. With the aid of Jesse's love sick lab assistant Giovanni, they set up a home clinic to help horny guys get rid of their boners. Tony De Sergio is the first client in and Lilly takes a full body approach to working out his erection. Jesse services patient #2, Johnny Sins, by using her beautiful body to relieve his rod of love juice for a test sample. With the clinic's success, Jesse is able to send out a special ointment that Anna Morna and Tommy Gunn use to help him with his unwavering erection....

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