In Lower Canada, around 1850, sisters Augustine and Josephine Wilson suffer from a rare genetic disease that sets them apart from other women. They are secluded by their father, who is suffering from tuberculosis. After his death, they must confront a village dominated by religious superstition and fear of the devil. Hunted and perceived as she-wolves, they become the embodiment of rejection and emancipation, until a mysterious destiny leads them to their liberation.

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