Teenage Mutant Ninja Turtles III: The Manhattan Project is a side-scrolling beat-'em-up released by Konami for the Nintendo Entertainment System (Family Computer) in Japan in 1991 and for the Nintendo Entertainment System in North America in 1992. It is the third video game iteration of the Teenage Mutant Ninja Turtles for the NES. The game features play mechanics similar to the previous game, Teenage Mutant Ninja Turtles II: The Arcade Game, but it is an original title for the NES without any preceding arcade version.

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