Pokémon Puzzle Challenge, originally released in Japan as Pokemon de Panepon (ポケモンでパネポン, Pokemon de Panepon), is a video game for the Game Boy Color. It is based on Panel de Pon, only with characters from the Pokémon franchise. The characters in Pokémon Puzzle Challenge are based on those in the Gold and Silver games, while those in Pokémon Puzzle League—its Nintendo 64 equivalent—were based more on the anime characters. However, the game is also focused around beating the Johto leaders in a puzzle challenge in Johto region. The game play mode is divided into 1 Player, 2 Player, and Training.

Pokémon Puzzle Challenge, originally released in Japan as Pokemon de Panepon (ポケモンでパネポン, Pokemon de Panepon), is a video game for the Game Boy Color. It is based on Panel de Pon, only with characters from the Pokémon franchise. The characters in Pokémon Puzzle Challenge are based on those in the Gold and Silver games, while those in Pokémon Puzzle League—its Nintendo 64 equivalent—were based more on the anime characters. However, the game is also focused around beating the Johto leaders in a puzzle challenge in Johto region. The game play mode is divided into 1 Player, 2 Player, and Training.